Cross-React : Prediction of allergen cross-reactivity

For cross-reactivity prediction, please select group of amino acids in epitope location, and upload a PDB file of interest. The server will use this information to search all allergenic protein structures listed in Structural database of allergenic protein, SDAP. Please do not upload a PDB complex. Use only one PDB chain name or a monomeric protein structure. You can use a PDB id or one word for your pdbfile name. Average processing time per query is ~90 sec. Latest release version 2.0. Minor bug fixed from version 1. Now users can search more than 1500 allergen structures available in in SDAP database for crossreactivity.

References:
Negi SS and Braun W, Cross-React: a new structural bioinformatics method for predicting allergen cross-reactivity. Bioinformatics 33 (7): 1014-1020, 2017. pdf

Note: If you have a protein complex, then list of amino acids in IgE binding site can be calculated from https://curie.utmb.edu/pdbcomplex.html or https://curie.utmb.edu/usercomplex.html utility.

List of amino acids in IgE binding site:
e.g. 42,43,44,45,46,47,48,49,50,51
(Please use surface exposed residues only )

Project name:
Email Address: For information purpose only
Patch size (A):
Area cutoff (A^2):
Correlation cutoff: e.g 0.8
PDB file name:

How to use the webserver: Please see below a screenshot for the cross-react analysis of Bet v 1.

Example input from the WebServer.

Example output from the WebServer.

Cross-React: Prediction of allergen cross-reactivity