Na+/dicarboxylate cotransporter 1
	PRIMARY STRUCTURE PREDICTION hmmpfam       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......   score       MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS Na_sulph_symp 1.1e-209       -----KKLIWKLLALLAVLLIIWFLPAPDGLSSKAWHLFAIFIATIVGLILEPVPLGVIALIALSLSAVLTGTLSSWALSGFSNTTTWLVFLAFFIAAGFEKTGLGKRIALVLVKALGKRTARLGLGYALVFSDLLLAPAIPSNSARAGGIIFPVIKSLPVASSNVEEGLFGSTPEKGEPSPQKEVTKL---DNGQALPVTSASSEGDAHLSQKSERIGAYLMWTVYQSTSITSAMFLTAMAPNLLALGLANKLFPILGVEISWLSWFLAALPPGIILLLLVPLLLYVLYPPEIKSSPFGIGEKMQEQQ--QDAKRIAKTELKEMGPMSKREKALLGLFLLLLLLWIFGGPGFFLGWGNLASLGAKGESMIDATTVALIVLVLMLLLRIKFPGLTQDPENPGKLKAPLGIVDWKIVKNKTAWNTLIWFGALIALAGGLNKSGFIEWLGNALVTSLSSPLMAFIILVLLYYLSHYFFASATAHIAAMLPIFLAVAQALPGAPLLLALLLAFASSLGFLTPYGTGPAPIYFGSGYVKVKDWWRLGFILSIIGLIIWLLVGAL CitMHS 0.15       --------------------------------------LGILMVLVFLMLIMYKRLSPIIALIIILAALIGGPPMMEDGVSFIAPTFLMLLFGILFFGIMEDTGLFDPLARKILRIVKGDPWKILVGTAVLAALVSLDGDGFTTVLILTPAALPLYKRLN---------------------------------------LPPRL-----------------LLGAIALGANIGNMLTPWGGPQNRA----IAANSFFGTLGVDFAEFFAPMIPAMIAGLILVLGALTLGKKERKRLGETFLREEIANKKEASQALENASKEEEDLRPKLLWLNSLLTLALIVLL-------------------------------------ILLHSLP-AILPL------PLLFTIGIAALNYPNLKDQKAGNALLVVAALFAAGEFVGVLGGTGMVDALAESLLRIIPPLLAVIIILLSIPGSASGSNDAAYFGVLPILAEAAAAYGIPLLELARASALGQPLG--------------------------------------------- Glycos_transf_4 0.21       --------------------------------------------------------------------------------------VLAVLLVILGIGLLDNFGLSARAALPLLVLTGVFLVLPFLGYILLMVFLLVGCSNQGIIAAVALALIALLQGL----------------------------------------R-AA-FAKYLHIYRDRHQLSLALISLALAGALLGAVVAILGHFEITL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Na_H_antiporter 0.31       ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GATFGDKSSPLSDTTGLAAGFQKTDLFDHIAHGMFVTTANVYAAFALLMLGMVVG----LRDVGSMLRAEERART-------------------EELEELSLLGSVLDLIVPIAVLIILAVTGVLALGV-AFIIAIA---FQNTDVLDALIYGALAGFIVSTLLGL----------SEIDKLLNIKSM---AGIIFILILAWGFGGV--LEATGGTEVLLSSLLKGIGKSKPLIIFLVALLVAFAT--GTSWGTIPIIGPIAVPLADELGLSPMKALSDSTILSTTGLSTPFPYFLFYAPILAIPLGVFGL--------------------- MFS_1 1.1       ----------------------------------------------LFLATFLAGLGRSLLGPALP-YLAEELGLSPTQIGLLLSAFSYALAQPLAGRLSDRFGRRRKPVLLLGLLLFALGSLLLLWLLLILRALLLAPAAAALIADWFPPEER----------------------------------------------------------------GRALGIVAGFGLGAALGG----------------PLLGGLLAALGWRAAFLILGILALLAALLVLFLLPEPPAKKSGKPEEEEALI--------------PLR-LLL-P-LLLILLALFLLLAAFLALLTFLPLYLLLPLLLS-SAGLSLSLLALGLGGLLGGLLLGGRLSDRLGGEAEAE-RRRLLLLGLLL----------------------------------------------------LALGLLLLAFAPSLS----LLLVALLLLGLGFGGVFPALNALAPEERGTASGLYNTAGSLGGALGPLLGGLLLD----------------------- 7tm_3 1.3       --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVALAVLGVKASNRELSYLLLIGLILCFLCSFLFIGKLFGLGFTLALLAKTIRVLATKPGSGQRRKFISPWAQVLIVLILTLIVIICVIWLVVEPPRPDKDIHSEKEKKGSVVAFVVVLGYLGLLLPDNFNE-AKFITFSMFCIVWVAFIPIYLSTPGDYKVQVAVEIFSILASSTGLLGCIF---AP-KCYIILFKPEKN--------------------------------------------------------------------------------------------------------------------------------------------------------------- BPD_transp_1 1.3       -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPNSLLLTLIATLLALLIGILLGIIAAYALVRRGRRLD----RLLRPLIDVLLAIPSLVLALLLVLALLSLAPVALIRRAALDSLPSDYVEAARALGASRWQIFRKIILPNALPPILTGLALAFGAVVGELATLSFLGGLGYL-IIEAILNLDYPLIQGPVLALALLVLLLNLLADILQRLLDPRVRR----------------------------------------------------------------------------------------------------------------------------------------------------------- NhaB 1.7       EITLGQALLKYKLAIIVFLI-IN----PIVFFLISPFVA-GWLLVAEFIFTLAMALKCYPLQPGGLLAAIGMTSAKQVKEEIAANLEVL----LLLVFMVAGIYFMKQLLLFVFLLLKIRSKILLLAFCLAAAFLSAFLDALTVIAVVISVAVGFYSIYHKVASGKSLSEDK---DITDDSKIEE----------------------LSKEELEKFRFLRSLLMHAGVGTALGGVMTMVGEPQNLIIAKQAGWNF-----GEFFIRMSPVTVPVFICGLLTCLLVEKLKLFGYGAQLPDKVRKILSDYDRQERAKRTKQDKIKLIGVWLIVALALHLAEVGLIGLSVIILATSFTG---VTDEHALGKAFEEALPFTALLAVFFSVVAVII---DQ------KLFSP--IIQFVLQAEEK-TQLAL-----FYLFNGL----LSSVSDNVFVGTVYINEAKAALEEGVITREQFELLAVAINTGTNLPSVATNGQAAFLFLLTSALAPLIRLSYGRMVYMAL-PYTLVLSIVGLLAIEFLLEPATEWLADAGLIAL---- UbiA 1.9       -----------------------------------------------------------------------------------------------------------------------------TLLVLAPVLAGLALAALLLLALLGFLARAAGNVINDY-FDRDIDAINERRI----------------------STPNRPLPSGRISPREALTFALLLLALGLALALLLNFLLALLGLALAVLYSYPTRLTPLGTVVLGAA---GALPPLMGWVAVTGLSVVAILLFLALFLWTAPHALEEVERAKKIALLLLAVAVALLLLLGLLGGGILYLIVVLLLGALLLY-------LAIKLVRDPEKIEKAFVASLILLLVLFAALLLAF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Papilloma_E5 2.1       -------------ILLVFLLCCVLLCLCLLLPLLLSVYAALLLLVLLLWVFVTSPLRAFIVYLIFLYPLFLIHLHAQYLLQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------             PRIMARY STRUCTURE PREDICTION hhsearch_cdd       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......   score       MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS Na+/dicarbox 1137.66       KRKIVNTLLQYRSLLVLNRTPLLLLPLDKLLHSSEARCAYVILVMAVYWVTEALPLAVTALLPIVLFPFFGIVRSNEVANEYFKDTNLLFLGGLIMALAVEKCNLHKRIALKVLRKVGVEPARLMLGFMGVTAFLSMWISNTATTAMMIPIATAVLQELPSFNDEEQHRSVSHLWAVEALVPLLTVFFPILKDETGKPMSPTSSSILSTMWSSTIMLLLKGFTLGIAYSAYIGGTLTITGTAPNLVLLGNMNVRFPLSMWVSNFASWLFFSFPPMLRYLLASWPFLQALFLGIALAANIGGMSSPISSPQNIVAKKVIKPEYDGLGPMFFAEKPVFILFILLVWLWFTRDPGFVPGWGDLFKPGF----FQSDSTSVVIITILLFCLPSQIPFGKSGFIAIIPIVVFFGLGLWKTVQFTFPWSIVLLLGGGFALAKGVSSSGLSSLIGNALKPLESLPVFAILLIFSLLILVVTEFVSNTATASIFIPILAELAEALGIHPLYLMLPTTLACSFAFMLPVSTPPNAIVFSMGDIKGKDMLKVGLFLNIGGPAILLLFMNT Na_sulph_sym 854.32       KKLIWKLLA-----LLAVLLIIWFLPAPDGLSSKAWHLFAIFIATIVGLITEPVPLGVIALMALSLSAVLTGTLSSWALSGFSNTTTWLVFGAFFIAAGFEKTGLGKRIALFLVKAMGKST--LGLGYALVFSDLLLAPAIPSNSARAGGIIFPVIKSLPVS-------------------------------------------FGSTPEKGSPRKIGAYLMWTVYQSTSITSAMFLTAMAPNPLALGLANKILGNE---ISWLSWFLAALPPGIILLLLVPLLLYKLYP--------------PEIKSSPEAKRWAKTELKEMGPMTFREKALLGLFLLLLLLWIFGGSLG-----------------IDATTVAIIGLVLMLLLR---------------------IVDWKDIKNKTAWNTLIWFGGLIALAGGLNKSGFIEWLGNTLVTSLSGPLMAFAILVLLYYLSHYFFASATAHTAAMLPIFLAVAQALGAPPLLAALLLGFASSLGFLTPYGTGPAPIYFGSGYVPVKDWWRIGFILSIIGLIIWLLVGAL SLC13_permea 716.45       --------------------------------------LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDIS--------------------------------------------------------PSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG---FSFFEFTPIGLPLLIIGLLYLWFIGKRLLPDKRKQINGG-----RTLKQQEEENLALVLQLPLSERPTRKSKFRLAVLIITIVLLAALA--AITGL-------------LPVSVAIAIGAIVLVFGG---------------------VLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPL ArsB_NhaD_pe 574.01       ---------------------------------------------YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLAR-ASKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKL-------------------------------------------------------GLSPPVPLLLALAFAANIGGAATPIGNPPNLIIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLL-------------PDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIP-------------------LGLIALLGALLLLLLLVR---------------------GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPPALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPLTLLSLVVSLLYL-- CitT Di- and 565.13       MVK-----RLDLLALLVLLALVLLGPVPF-GLSGFAWLFAILVAAIILWILEAIPLFALAILVIVLLVLSGFSASKLALSGFANSTIWLIFGLFLLSKGLEKTGLGKRLALHLLRFFGTTPRGLALGLVLLTLFLSAFPSNTATGGIMLPLILSLSPLLGSPPRD---------------------------------------------------KIGKRLILGIALAANIGSALTPIGNPPNIIAAGLLNPIS------LSWGEWFLAMLPLGILLLLLLLLLLYKLFP-PREIKETPNNPVA------------AKRELKELGPLLRDEKLLLGIFLLLLLLWIFGKLGKI-----------------DATLIALIPVALLLLAG---------------------VLTWKEVYKKIDWGTLILFGGLIALGSALSKTGAIAWIAGLLAGLGGLGPFAILLLLLLLTLVLTLFASNTATAIAMVPIAIALASALGGAPLLLLMLVAVSASGGFLTPVGSPPNPIALGSGYVKFKDWWKVGFILSIVLIIVLLVIGLL P_permease P 464.93       -----------------------------------------FIITYALIIFEKVHRTVAALAGALWLVILGLATLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPV--------------------------------------------------------PVLISEVIAANIGGAATLIGDPPNIMIGSAA---------GLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLALAELEPKYPIKDKVLL-------------LKSLTILTLVIIGFVLHSPLG-----------------VSLGWIALLGALLLLLLA--------------------DKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGNGTLIGASANVVAAGIAKISFWEFLKVGFPIMLVSLILATVYLL- YbiR_permeas 392.82       -------------------------------------------LALGRVPGLRLDRWAIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAG-SPRRLLFLLVLLSGILSALLTNDTACLVFTPIVLELARVAGLPPI--------------------------------------------------------PLLLALATAANIGSAATPIGNPQNLLIASES---------GISFPFFLAAMAPLALLGLLLLLILLLVLFP-GELKGLPLDKATKEEGVGARKL------------------AVKLLVLILLLLVAFLALLGVIPLW------------------TAALVAAVLLLLT---------------------RLKPRRVLKKVDWGLLLFFAGLFILVGGFAQGLPLEGLSRLLPLLDS------VLSLFLVSIGLSQLISNVPAVLLLLPFLPSADEK-------DWLLLAAGSTIGNLTLLGSAANLIVAEAARLSFGEFLKYGVPLTLLTAAIGILWL-- ArsB_permeas 339.16       ----------------------------------LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGWDVTLTLIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRAL---------------------------------------------------------GAKKPFLYACAFIADAASLPLPISNLVNIVTAGYF---------GIGFTEYAALMFLPSIVSILATYVVLYLFF---------------RRALPKRLETASVKKPSLAIKDPLLFGLAWTLLVLLVVSAFGVDILLIPPSF------------------IAGVLALIFLLLARR-----------------GGAINPLKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQGLLAAILGVGLLAAFLSNVMNNLPAVLIGALALAA-----GHAPEALVYANLIGVDLPKLTPIGSLATLLWKGIR-VSWGYYLKVGLIVTPPVLVVTLAALI- ArsB Arsenic 275.37       ----------------------------------LAFAIFLLTLVLVIWQPKGLGIGWSASIGAVLALILGVVAFGDVLTVTGINATLTFVAVILISLILDEIGFFEWAALHMAKARNGRGRRMFVFIVLLGAIVAALFANDGAALILTPIVLAMVRAL---------------------------------------------------------GFNKPFIIASGFIADTTSLPLVVSNLVNIVSADYF---------GIGFIEYASRMVPPNLFSLIASILVLFLYF----RKSIPKTYDLEQ-----------LKPPRAAIKDRATFRLSWIVLLLLLVGYFASEFLGIPVSA------------------VAGAIAAIFLIVAGK-----------------SRAVHTKKVVKEAPWQIVVFSIGMYLVVYGLKNAGLTDLLSDVLNRMADHGLFAATLGMGFIAAFLSSIMNNMPTVLIDALAIQG-SDTTGPVREAMIYANVIGSDLPKITPIGSLATLLWLHVLKISWGTYFKTGIILTIPVLLVTLSGLYL ArsB Na+/H+ 267.76       ------------------------------MMMLLALALFIFTLVYVLIRPRKLPRAWAALLGALLALFLGIVTPEDALVGIDWNVILLLLGMMIIVLLLDESGFFEWLAIKMVKRSKGSGLKLLLLLVLLGALLSAFLDNDTTALLLTPIVLAVARALGVNPV--------------------------------------------------------PFLIAEVFIANIGGLATPVGDPPNIIIASAA---------GISFNDFLANMFPPSLISLIATLVVLYLLFR---RKVIPERYDDLLLLDPR----EAIRDRLF---------KLSLVVLALVLIAFLLLP--FLG---------------IPVSLVALVGAAILLLLA---------------------RLSPREILRGVEWSTLLFFIGLFIVVGGLENAGVTEDLASVLKALSSGGLAAATLGIGWLSGLLSSVLDNVPTVLTFAPIIKGLAANGMGK-EPLWLALALGADLGNLTPIGSAANLVWLGVVPISFGEFFKVGIIVTLPSLFITLLYLYL             SECONDARY STRUCTURE PREDICTION TM helices     1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......           MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS tmpred         ++++++++++++HHHHHHHHHHHHHHHHHHH--------------------HHHHHHHHHHHHHHHHHHHHHH+++++++++++HHHHHHHHHHHHHHHHHHH------------------HHHHHHHHHHHHHHHHHH+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++HHHHHHHHHHHHHHHHHHHH---------------------------HHHHHHHHHHHHHHHHHHH++++++++++++++++++++++++++++++++++++++++++++++HHHHHHHHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHHHH+++++++++++++++++++++++++HHHHHHHHHHHHHHHHHHHHH-----------------------HHHHHHHHHHHHHHHHHH++++++++++++++++++++++++++++HHHHHHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHHHHHHH memsat         +++++++++++++++HHHHHHHHHH-------------HHHHHHHHHH++++++++++HHHHHHHHHH----------------HHHHHHHHHHHHHH+++++++++++++++++++++++++++++HHHHHHHHHH-----------HHHHHHHHHH+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++HHHHHHHHHHHHHH---------------------------------HHHHHHHHHHHHHH++++++++++++++++++++++++++++++++++++++++++++++HHHHHHHHHHHHHH---------------------------HHHHHHHHHH+++++++++++++++++++++++++++++++++++++++HHHHHHHHHH---------------------------HHHHHHHHHH+++++++++++HHHHHHHHHH-----------HHHHHHHHHH++++++++++++++++++++++++++++++HHHHHHHHHH------- tmhmm         ---------HHHHHHHHHHHHHHHHHHHHHHH++++++HHHHHHHHHHHHHHHHHHHHHHH--------------------------HHHHHHHHHHHHHHHHHH++++++++++++HHHHHHHHHHHHHHHHHHHHHHH---------------------------------------------------------------------------------------------------------------------------HHHHHHHHHHHHHHHHHHHHHHH+++++++++++++++++++++++++++++++++++++HHHHHHHHHHHHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHHHHHHHHH+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++HHHHHHHHHHHHHHHHHHHHHHH--------------HHHHHHHHHHHHHHHHHHHH++             SECONDARY STRUCTURE PREDICTION Protein Order     1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......           MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS coils         -----------------------------------------------------------------------------------------------------------------------------------------------------------CCCCCCCCCCCCCCCCC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- disprot         -------------------------------------------------------------------------------------------------------------------------------------------------------------DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD-----------------------------------------------------------------------------------DDDDDDDDDDDD-------------------------------------------------------DDDDD---------------------DDDDDDDDDDDD-----------------------------DDDDDDDDDD-----------------------------------------------------------------------------------------------------------------DDD disopred         DDD------------D--DDDDD-DDDDD-------------------------------------------D-----------------------------------------D----D--------------------------------------DDDDDD-DDD-DDDDDDDDDDDDDDDDDDDDDDDDDDDD-DDDDDDDDDDDDDD---------------------DDDD-------------------------------------------------------------DDDDDDDDDD--------------------------------------------------------DDD--------------------------DD--DDDDDDDD--------------------------------------------D-DDD----------------------------------------------------------------------------------------------------DDDDD spritz         ----------------------------------------------------------------------------------------------------------------------------------------------------------------DDDDDDDDD--DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD------------------------------------------------------------------------------------------DDD------------------------------------------------------------------------------------DDDDDDDDDDDDD------------------------------------------------------------------------------------------------------------------------------------------------------------             SECONDARY STRUCTURE PREDICTION Protein Solvation     1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......           MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS sable_acc         ---BB-BBBBBBBBBBBBBBBBBBBBBBB-B---BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-B--BBB-BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB------B-----B--B-B-----------B-------B------------------B-BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-BB---BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-B-B---B-B------------B--BB---B--BB-B-B-BBBBBBBBBBBBBBBBBB-B-BB-BBB-BBB--B-BBBBBBBBBBBBBBBBBBBBBBB-BBBBBBBBBBBBBBBBBBBBB-B--BB--B-BBBBBBBBBBBBBBBBB--BBBBBBBBBBBBBBB-BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-BB-BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-BBBBBBBBBBBBBBBBBBBBBBBBB accpro_sol25         ---BB-BBBBB--BBBBBBBBB-BB-B-BBB----B-BBBBBBBBBBBBBB-BB--BBBBBBBBBBBBBB-BB-B--BB--BB--BBBBBBBBBBBBBBB--B-BB-BBBBBBBBBB-B-B-BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-BB------B-------BB-B--------B--B----------B---------------B-BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-BB---B------B-BBBBBBBBBBBBBBBBBBBBBBBBBBBB-B-B---B-B-----------BB--BB---B--B--B-B--BBBBBBBBBBBBBBBBB---BB--BB-BBB------BBBBBBBBBBBBBBBBBBBBB-B--B------------B-BBB-B--BB--B-BBBBBBBBBBBBBB-BB--BBBB-BBB-BB--B--B-B-BBBBBBBBBBBBBB-BBBBBBBBBBBBBBBBBBB--B-B-BBBBBBBBBBBBBBBBBBBBBBBBBBBBBB---B-B--BB-BBBBBBBBBBBBBBBB--- jnet_sol25         BBBBB-BBBBBB--BBBBBBBBBBBBBBBBB------BBBBBBBBBBBBBB--B-B-BBBBBBBBBBBBB--------B--BB-BBBBBBBBBBBBBBBB----BB-BBBBBBBBBBBB---BBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-BBB--BB-----------BBBB-B----------------------------------------BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-BB---B------B-BB--B---B-BBBBBBBBBBBBBB--BBB--B---B-------------BB--BB---B-----B-B---BBBBBBBBBBBBBBBB---BB-BBB-BBB--------B--BBBBBBBBBBBBBBB-----B--B------------BB-B--B---B-BBBBBBBBBBBBBB--B--BBBB-BBB-BBBBB--B-BBBBBBBBBBBBBBBBBBBBB-BBBBBBBBBBB-BB-BB-BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB-BBBBBBBBBBBBBBBBBBBBBBBBBBBB-B accpro_sol5         ---B---B------BBB--------------------BB-----------------BB------BBB----------BB--------BB------BBBBB----B---BB--BB--B------BBBBBBBBBBBBBB-B---B-BBBBBBBB-BBB--B----------------------------------------------------------BB-BBBBBBBBBB-B-BBB-B------BBB---B----------B-BB-BB-BBB---BBB-----B-BBB-------------------------B---B---------------BBBBBBBBBBBB-B-------------B------------BBBBBBBBBBBBBB----------------------BB----B---B-B-BBBBBB-B-BBB--B----BB--BB--B---------B-BBBBB---------------B-BBB--B--BB---------BBBBBBBBB-B---BB------BBBBB--------B---BB---------------- jnet_sol5         --------------BBBBBB-BBBBBB----------BBBBBBBBBBB------------------------------B-------BBBBBBBBBBBBBB--------BBB--B-BBBB----BBBBBBBBBBBB--B-----BBBBBBBBB--BB--B-------------------------------------------------------------BBBBBBBBBB-B--B--B-----BBBB---B------------------------------------------------------------------B-----------------BBBBBBBBBBBB--------BB--------------------BBBBBBBBBB----------------------------B-------BBBBBBBBB-B--------BB--BB-BB--B------BB-BBBBBBB-BB--B----BBB-BBBBBBB-BB--B----B---B-------B-B-------BB-BBB---------BB-BBB-B-BBBBBB--B-B-- profsec_acc         ------------BBBBBBBBBB-B-------------BBBBBBBBBBBBB-------BBBBBBBBBBBB---------B------BBBBBBBBBBBBBBB--------BBB-BB---------BBBBBBBBBBBBBBBB--BBBBBBBBBBBB-BB-B------------------------------------------------------------B-BBBBBBBBBB-B-B-B--------BBBBB-B------------BB-BBBBBBBBBBBBBBBBBBBBBB-------------------------B---B----------------BBBBBBBBBBBBB---------------------------BBBBBBBBBBBBB----------B-BBB-B-BB--------B---B---BBBBBBBBBBBB--B--------BB--B---------BBBBBBBBBBBBBB-BB---BBBBBBBBBBB-BB---------BBBBBBBBBBBB-B---------BB----------B--------BBBBBBBBB---- accpro_sol0         ---B---B-----------------------------B--------------------------B------------BB--------BB-------B-B---------BB--BB---------BBBB---BB------B-----BBBBB-BB--BB--B----------------------------------------------------------BB-BBBBBBB-BB---BBB-B------B-B---B----------------B--B----B---------B-B-------------------------B---B----------------BBBB-B--B------------------------------BBBBBBBBBBBBBB----------------------BB----B-------BBBBB----BBB-------BB--BB--B-----------B---B---------------B--------------------BBBBB-----------------BBB----------B--------------------- jnet_sol0         --------------B--------B--------------BBBBBBBBB-------------------------------B------B-B-B----BB-BB----------B-----------------B-B---BB--------BBBB----B--------------------------------------------------------------------B--BBBB-B---------------BBB-----------------------------------------------------------------------------------------BBBBBB----------------------------------------BBBB--------------------------------------BBB---------------B--------------------------------------BB-BB-BB------------------------------------BBB----------B--BB-------BBB-------             SECONDARY STRUCTURE PREDICTION Secondary Structure     1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......           MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS sam         --HHHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHHHHH---HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHH--------H--HHHHHHHHH------------H--HHHHHH--H-HH---HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHH--HHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH--------EEE---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHH-----HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHH--------EEEEEE-----HHHHHHHHHHHHHHHHHHHHHH--- sspro4         --HHHHHHHHHHHHHHHHH----------E--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-H----H-----HHHHHHHH---HEEEEHHHHHHHHHHHH--HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH--------------EEE------------------------------------HHHHHHHEEEEEEEEE-----EEEE----HHHHHHHHHH-----------HHHHHHHHHHHHHHHHHHHHHHHHHHH-----------------H-HHHHHHHHHHHHHHH-----HHHHEEEHHHHHHHHHHE-----------HHHH------------EEEEEEEEEEEE-----------------------EE-HHHHHH-----EEEEE--HHHHHH---H-HHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----HHEEHHHHHHHHHHH---------EEEE----EEEHHHHH---EEEEEEEEEEEEEE-- psipred         ---HHHHHHHHHHHHHHHHHHHHH------------HHHHHHHHHHHHHH------HHHHHHHHEE--------HHHHHHHH----EEHHHHHHHHHHHHHHH---HHHHHHHHHH-------HHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHH----------------------HHH-------------------------EEEEH--HHHHH-------------HHHHHHHHHHHH-------------------HHHHHHHHHHHHHHHHH---------------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH---------HH---------------HHHHHHHHHHHHH-------------------------HHHHHHH----HHHHHHHHHHHHHHHHH--HHHHHHHHHH------HHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHH-----HHHEEEEE---EEEEEHHHHHHHHHHHHHHHHHHH--- jnet         -------HHHHHHHHHHHH--EEEEE---------EEEEEEEEHHHHHHH-------------------------HHHHHHHHHH-EEEEEHHHHHHHHHHHHHHHHHHHHEEEEEEE----EEEEEEEEEEHHHHHHH--HHHHHHHHHHHHHHHHHH-----------E--EEEEE------------------------------------HHHHHHHHHHHHHHHH----EEEE----HHHHHHHHHHHH-------E----------------------------------------------HHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHEEEEE----EEE-HHHHH--------EEE--HHHHHHHHEEEEHHHH--------------------EEHHHHHH-----EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH-----EEEEEEEEEEEEEEEEEE--HHHHHHHHHHHHHHHHHHH----EEE--------EEEEEE-----EEEEEE--EEEEHHHHHHHHHHHHHHHHHHHH---- porter         ---HHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-------EEE------------------------------------HHHHHHHHHHHHHHHHHHH----------HHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH--------HHHHHHH---------HHHHHHHHHHHHHH--------------------------HHHHHH---HHHHHHHHHHHHHHHHHHH--HHHHHHHHHH------HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHH--------EEEE------HHHHHHH--HHHHHHHHHHHHH--- sable         -HHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH------HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH--------------------------------------------------------HHHHHHHHHHHHHHH-------------HHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH----------------------E--HHHHHHHHHHHHHHH------HHH----HHHH--------HHHHHH----HHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH---------EEEE------HHHHHHHHHHHHHHHHHHHHHH--- prof         -HH-HHHHHHHHHHHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHHH----HHHHHHHHHHHEEEEE---HHHHHHHHH--HHHHHHHHHHHHHHHHH---HHHHHHHHHHHH----HEEHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHH---------------E-E--------------------------------------HHHHHHHHHHHHHHHH----EEE----HHHHHHHHHHHHH-----EEE-HHHHHH---HHHHHHHHHHHHHHHHHH-------H----------HHHHHHHHHHHHHHH-----E-HHHHHHHHHEEEEEEEE---------HHHH-------EEE---HHHHHHHHHHHHH-----HHH-----------------HHHHHH---HEEEEE---HHHHHHHHHH---HHHHHHHHHH------EEHHHHHHHHHHHHHHHH--HHHHHH-HHHHHHHHHHH----HHHHHHHHHHHHHHHH--------EEEEE-----HHHHHHH---HHHHHHHHHHHH--- profsec         --HHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHH-----HHHHHHH---HHHHHHHHHHHHHHHHH---HHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH----------------------------------------------------------HHHHHHHHHHHHHHH--HHHH----HHHHHHHHHHHH---------HHHHHHHH-HHHHHHHHHHHHHHHHHH---------------------HHHHHHHHHHHHH-------HHHHHHHHHHHHHHHHH----------HHH------------HHHHHHHHHHHHHHH------HHHHHHHHHHHHHH----HHHHHH---HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH---------EEEE------HHHHHH---HHHHHHHHHHHH---- consensus         --HHHHHHHHHHHHHHHHHHHHHH---------HHHHHHHHHHHHHHHHHH----HHHHHHHHHHH--H-----HHHHHHHH---HHHHHHHHHHHHHHHHH--HHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHHH--------------------------------------------------------HHHHHHHHHHHHHHH------------HHHHHHHHHHHH---------HHHHHHHH-HHHHHHHHHHHHHHHHHH-------------------HHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHHHHH-----------HHH-------------HHHHHHHHHHHHH-------------------------HHHHHH-----HHHHHHHHHHHHHHHHH--HHHHHHHHHHH-----HHHHHHHHHHHHHHHHHHH--HHHHHHHHHHHHHHHHH-----HHHHHHHHHHHHHHH---------EEEE------HHHHHHH--HHHHHHHHHHHHH---             TERTIARY STRUCTURE PREDICTION pdbblast       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......   score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS 2c1v A  0.91   30%        ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAIPEKMTAIKQTEDNPEGVPLTAEKIELGKVLFFDPRMSSSGLISCTCHNVGLGGVDGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1vj2 A  2.8   30%   b.82.1.10     -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FVMRLFTVEPGGLHPWEHEIFVKGKLTVLKEQGEETVEEGFYIFVEPNEIHGFRNDTDS---------------------------------------------------------------------------------------------------------------------------------------------------------------- 1q7z A  4.1   41%        -----------------------------------------------------------------------------------------------------------------------------------TAFLVLGISKGLSSAIMNPLDETLMKTLNAT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1szi A  5.4   33%        -------------------------------------------------------------------------------------------------------------------------------------------------------AQETLQQLTSVMESVKQGVDQRLGEGQEKLHQQKTPQDAEKDPAKPEQVEARALSMFRDITQ------QLQSMCVALGASIQGLPS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------           TERTIARY STRUCTURE PREDICTION blastp       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   2c1v A  0.76   30%        ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAIPEKMTAIKQTEDNPEGVPLTAEKIELGKVLFFDPRMSSSGLISCTCHNVGLGGVDGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1vj2 A  1.4   32%   b.82.1.10     -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FVMRLFTVEPGGLHPWEHEIFV-LKGKLTVEQGEETVEEGFYIFVEPNEIHGFRNDTDS---------------------------------------------------------------------------------------------------------------------------------------------------------------- 2ihd A  1.7   40%        --------------------------------------------------------------------------------------------------------------------------------------LEFWLAKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTRELQEPSAQGKVHSLMEKDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------         TERTIARY STRUCTURE PREDICTION ffas       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   4hb1  -7.35    8%   k.8.1.1   1.4.4.1  --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKQALQQAQQLLQQAQELAKKGGGEELLKQALQQAQQLLQQAQELA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1pw4 A  -5.83   10%   f.38.1.1     ----------------------------------------IFLGIFFGYAAYYLVRKNFALAMPYLVEQ-----------GFSRGDLGFALSGISIAYGFSKMGVSDRSNPRVFLPAG----LILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQK---------------------------------------------------GGIVSVWNCAHNVGGGIPPLLFLLGMA---------WFNDWHAALYMPAFCAILVALFAFAMM-------------RDTPQSCGLPPIEEYKNDYPDDYNEKAEQELTAKQIFMQYVL---------------------------------LLWYIAIANVFVYLLRYGILDWSPTYLKEVKH----------FALDKSSWAYFLYEYAGIPGTL-LCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYGAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVM-- 1oed A  -4.86    8%   f.36.1.1     ----------------LYFVVNVIIPC----------LLFSFLTGLVFYL-EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIITVVVINT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1oed C  -4.76   13%   f.36.1.1     ----------------LFYVINFITPC----------VLISFLASLAFYL-EKMSTAISVLLAQAVFLLLTSQRLPETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1oed B  -4.55   18%   f.36.1.1     ----------------LFYIVYTIIPC----------ILISILAILVFYL-EKMSLSISALLAVTVFLLLLADKVPETSLSVPIIIRYLMFIMILVAFSVILSVVVLNL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2b5f A  -4.4    8%        ------------------------------------------------AIAEFIATLLFLYITVATVIGHSKETVVCGSVGLLGIAWAFGGMIFVLVYCTAGSGGHINPAVTFGLFLARKVSLLRALVYMIAQCLGAICGVGLVKAFMKGPYNQFGGGANSVALGYNKGTALGAEIIGTFVLVYTVFSATDPKRSAR---------------DSHVPILAPLPIGFAVFMVHLATIPITGTGINARSFGAAVIFNSNKVWDDQWIFWV-------FIGAAVAAAYHQYVLRAAAIKALGSFRSNPTNLEQKLISEEDLNSAVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2grx C  -3.99    9%        -------------------------------------------------------------------------------------------GQVKVKFDVTPDG-----RVDNVQILSAKPANMFEREVKNAMRRWRYEPGKPGSGIVVNILFKINGTTEIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1l4a E  -3.95   11%   h.1.15.1     ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENAEEEAAAIEEARREAEERRKEKHRKMEEEREEMRQTIRDKYGL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2bg9 B  -3.91   19%        -----------------FYIVYTIVPC----------ILISILAILVFYLGEKMSLSISALLALTVFLLLLADKVPETSLSVPIIISYLMFIMILVAFSVILSVVVLNLHHRYVAMVADRLFLYIFITMCSIGTFSIFLDASHNVPPDNPFA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------         TERTIARY STRUCTURE PREDICTION hhsearch       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   2nq2 A  31.21   11%        ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQPDSYPKILFGLTLLLVITAVISLGIGRYSLSVPQIGQILWAKATALEIDPVQQQVIFQVRLP-------------------------RIL-------TALCVGAGLALSGVVLQGIFRNPLVNHIIGVTSGSAFGGTLAIFFGFSLYGLFTSTILFGFGTLALVFLFSFKFNQRSLLMILSGLFSALVSLLQYISDTPSIVFWLMGSFATSNWEKLLFFFVPFLLCSSILLSLS 2cfq A  27.26    9%        -------------------------------------------------------------------------------MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHISKGIIFAAISLFSLLFQ-------------------------------------------------------------------------------------------------------------PLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFCFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALGASIVGIMFTI------NNQFVF---------WLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTM-----------GELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSAL--------------EVVILKTLHMFEVPFLLVGCFK 2nwl A  28.21   13%        ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLYRKYIEYPVLIGLILGAIVGLILGHYGYAHAVHTYVKPFGDVRLLKMLVMPIVFASLVVGAISPARLGRVGVKIVVYYLLT-------SAFAVTLGIIMARLFNPGAGIHLAVGGQQAPPLVHILLDIVPTNPFGLPTIFFAIIL 1xfh A  30.33   12%        ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLYRKYIEY--PVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDVRLLKMLVMPIVFASLVVGAISPARLGRVGVKIVVYYLLT-------SAFAVTLGIIMARLFNPGAGIHLAVGGQQAPPLVHILLDIVPTNPFGLPTIFFAIIL 2i68 A  25.48   18%        ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNPYIYLGGAILAEVIGTTLMKFSGTIICYCASFWLLAQTLAYIPTGIAYAIWSGVGIVLISLLS-----WGFFGQRLDLPAII--GMMLICAGVLIINLLSRS 1l7v A  15.26   15%   f.22.1.1     --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTLARQQQRQNIRWLLCLS-----------------------------VLMLLALLLSLCA------------------GEQWISPGDWFTPRGELFVLLVGAALAISGAVMSNGAGVGLIAAVLLGQGQLPNWALGLCAIAGALIITLRFARRHLSTSRLLLAGVALG--------IICSALMTWAIYFSTSVDLRQLMYWMMGGFGGVDWRQSWLMLALIPVLLWICCQSR 2gfp A  24.15   13%        -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLLMLVLLVAVGQMAQTIYIPAIADMARDLNVREGQSVMGAYLLTYGVSQLFYGPISD-------RVGRRPVILVGMSIFMLATLVAVTTSSL 1ots A  16.46    8%   f.20.1.1     ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTDTPSLETPQAARLRRRQLIRQLLERDKTPLAILFMAAVVGTLVGLALVHTADNYPLLLTVA--------FLCSAVLAMFGYFLVRKYA--------------PEAGGSGIPEIEGALEDQRPVRVKFFGGLGTLGGGMVLGNIGRMVLDIF-RLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEE---MRPQFRYTLISIVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLY-LILGIIFGIFGPIFNKW 2fyn A  25.92   13%        IVPEWYFLPFYAILQIANFISFGIIDAKFFGV----------------------LAMFGAILVMALVPWL---DTSPVRSGRYRPMFKIYFWLLAADFV-------------ILTWVGAQQPYDWISLIASAYWFA-----------YFLVILPILGAIEK---------------------------------------------------------PVAPPATIEYSPATGGTKTVVAE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2akh Y  16.18   14%        -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFI-----------SIFALGIM---------------------PYISASIIIQLLTVVHPTL--------------AEIKKEGESGRRKISQYT---------RYGTLVLSIGIATGLPNMPGMQGNPGFAF---------YFTAVVSLVTGTMFLMWLGE-----------------------QITERGIGNGISIIIFAGIV-------AGLPPAIAHTIEQRQGDLHFLVLLLVAVLVFAVTFFVVFVERGQRRIVVNYAKRQQLKVNMA-GVIPAIFASSILFPATIASWLTTISLYLQPGQPLYVLLYASAIIFFCFFYTALVFNP         TERTIARY STRUCTURE PREDICTION sam       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   1iwg A  0.31   10%        ------EVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFF-----------GGYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGE----------------------------------------------------------------------------------------------GK---KGFFGWFNRMFEKS-----------THHYTDSVGGILRSTGRYLVLYLIIVVG------SYQERLSGNQAPSLYAISLIVVFLCLAALYESW---------------------------SIPFSVMLVVPLGVIGALLAATF------------RGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLD-AVRMRLRPILMTSLAFILGVMPL--------------------------------------------------------------------------- 2nq2 A  2.5   13%        ---------------------------------------------------------RILTALCVGAGLA-------LAIFFGFS-----LYGLFTSTILFGFGTLALVFLFSFKFNQRSLLMLILIGMILSGLFSALVS---------------LLQYISD---------------------------------------------------TEEKLPSIV------FWLMGSFAT------------------------SNWEKLLFFFVPFLLCSSILLSLSWRLNLLSLDEK-----------------------EAKALGVKMAPLRWLVIFLSGSLVACQ--VAISGSIGWVG--------------------------------------------------------------------------------------LIIPHLRLVGANHQSLLPCTMLVGATYMLLVDNVARSL---------------PISILTALIGAPL------------------------------------------------- 1hzp A  2.9    0%      180.1.1.1  ----------------------------------------------------------------------------------------------------------------------------------------------R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1wmw A  4.5   11%        ------------------------------------------------------------------------------------------------------------YRDLLQDYPRRGGKMLRGLLTVYSA-LEAGLEAATALELFQNWVLVHDDIEDGS-----------------------------------------EERRGRPALHRLHPMPLALNAGDAMHAEMWG----------LLAEGLARGLFPPE-VLLEFHEVVRRTAY-------GQHLDLLWTLGGTFDLRPEDYFRMVAHKAAYYTAVAPLRLGALLAGKTPPAAYEEGGLRLGTAFQIVDDVLNLEGGEAYGKERAGDLYEGKRTLILLRFLEE---------APPEERARALALLALPREAKPEAEV-----GWLLERLLASRALAWAKAEAKRLQAEGLALFQDLPGKEALDHLRGLLAALVE--------------------------------------------------------------------------------------- 1l7v A  4.7   12%   f.22.1.1     ------------ALAISGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPNWA--------------------------------LGLCAIAGALIITLILLRFARR-----HLSTSRLLLAGVALGIICSAM-------------WAIYFSTSVD--------------------------------------------------------LRQLMYWM------------------------M-----GGFGGVDRSWLMLALIPVLLWICCQSRPMNMLALGEISARQLGLP------------------------LWFWRNVLVAATGWMVGVSVALAGAIGFIG------------------------------------------LVIPHILRLCGLTDHRVL----------LPGCALAGASALL---LADIVARLALAAAELPIGVVTATLGAPVFI---------------------------------------------------------------------------------------- 1oye A  7.1   10%        ---------KTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIEGLPPKETKSMGQIQGALVGIAMVLSAVFVPMAFFG--------GSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGE----------------------------------------------------------------------------------------------GK---KGFFGWFNRMFEKS-----------THHYTDSVGGILRSTGRYLVLYLIIVVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESW---------------------------SIPFSVMLVVPLGVIGALLAATF------------RGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMD-------------------------------------------------------------------------------------------------------------- 2e9x B  7.1   13%        -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRLLPPEWMDVEKLEKMRDHERKEETFTRQQEAHAKLDNLTLMEINTSGTFLTQAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 2phh  8    0%      151.21.1.4  -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1x8b A  9.9    8%        ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 2j8s A  10    7%        ------EVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIEGLPPKEATRKSMGQIQGALVGIAMVLSA-------------MAFFGGSTGAIYRQFSITIVSAMALS-VLVALILTP---ALCATMLKP-IAKG-------------------------------------------------------------------------------------DH---GEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVL-----------YLIIVVGSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPF---------------------------------SVMLVVPLGVIGALLAATF------------RGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKG-LIEATLDAVRMRLRPILMTSLAFILGVMPLVI-------------------------------------------------------------------------         TERTIARY STRUCTURE PREDICTION mgenthreader       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   2ic8 A  0.361    9%        -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERAGPVT--WVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHAMHFSLMHILFNLLWWW----------YLGGAVEKRLG---SGKLIVITLISALLSGYVQSGVVYALMGYVWLRGERDGIYLQRGLIIFALIWIVAGWFDLFGSMANGAHIA------------GL---AVGLAMAFVDSLN 1t33 A  0.357   10%        AQWIADFLGEKFRPHAEKAERLFSQPAP---DRDAIRELILLACKNMIMLLTQEDT-----VNLSKFISREQLSPTSAYQ-------------LVHEQVIDP--LHTHLTRLVAAYTGCDTRMILHTHALLGEVLAFRLGKETTVTCHIDLILHGLTQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 1pw4 A  0.344   11%   f.38.1.1     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FKPAPHKARLPA---AEIDPTYRRLRWQIFLGIFFGYAAYYLVRKN----FALAMPYLVE-QGFSRGDLGFAVFLPAGLILAAAVMLFMVMFVLLFLCGWFQGMGW------------PPCGRTMV----HWWSQKERGGIVSVWNCAHNVG-----GGIPPLLFLLGFNDWHAALYMP-AFCAILVALFAFAMMRDTPQYKND-------------TAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYA----------GIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATNPAGNPTVDMIC---------MIVIGF---LIYGPVMLIGLHA 2gfp A  0.341   12%        ---------------------------------------------------------------------------------------------------------------------------------LLLMLVLLVAVGQMAQTIYIPAIADMARDLNVREGAV------------------------------------------------------QSVMGAYLLTYGVSQ----------LFYGPISDRVGRRPVILVGMSIFMLATLVAVTTSSLTVLIAASAMQGMGTGVGG-------------VMARTLPRDLYERTQLRHANSLLNMGILVSPLLLIGGLLDTMWNWRACY---------------LFLLVLCAGVTFSMARWMPETRPVDAPRTRLLTSYKTLFGNSGFNCYLLMLIGGLAGIAAFEACSGVLMGAVLGLSSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMNVWTLLVPAAFFFGAGMLFPLATFPFLLVGGSAMLPQTGQGSLGLLMTLMGLLIVLCWLPL 2fd5 A  0.340   22%        MLEAFEQLLGKRRELLG--------ELDPGLSGKERRALAALPATLAEVARLPEGFREVLSVEIMVTSLAESPEETDVALADL----VLMIGGLALARALGPGELSDRVLRAAKQAVN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1bl8 A  0.339   12%   f.14.1.1   1.1.18.1  ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALHWRAAGAATVLLVI----------VLLAGSYLAVLAERGAPGAQLITYPRALWWSVETATTVG---------YGDLYPVTLWGRCVAVVVMVAGITSFGLVT 1u6g C  0.334    8%        KEKSVKTRQCCFNMLTELVNV-----LPGAL--TQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNH--SPQVFHPHVQALVPPVVACVITSEAL-------LVTQQLVKVIRPLTPYIKDLFTCTIKRLKAADIDQEVKERAISCMGQIICNLGDNPNTLQIFLERLKNEITRLTTVKALTLIAG--SPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDIL-IKNYSDSLTAAMIDAVLDELPPLISESDMHVSQM----------------AISFLTTLAKVYPSSLSKISGSI----------LNELIGLVRSPLLQGGALSAMLDF--FQALVVTGTNNLGYMDLLRMLTGPVYSQTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSI--------RLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPE------YLPFVLQEIT--SQPKRQYLLLHSLKE--------------IISSASVVGLKPYVEN-----------IWALLLK 2nq2 B  0.324   10%        -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SYPKILLTLLLVITAVISLGIGRYSLSVQQQVIFQV----RLPRIL------TALCVGAGLALSGVVLQGGVTSGFGGTLAIFFGFSLYGLFTSTILFGFG--------TLALVFL-------LLMLILI--------GMILSGLFSALVSLLQYISDTPSIVFWLMGSFATSNWEKLLFFFVPFLLCSSILLSLS 2occ A  0.324   10%   f.24.1.1   1.5.14.1  ------------------------------------------------------------------------MFINRWL--FSTNTLYLLFGAW---AGMVGTALS-----LLIRAELGQPDQIYNVVVTAHAFVMIFFMVMPIVPLMIPRMNNMSFWL-LPPSFLLLLASSMVEAGGTGWTVYPPGNLAHAG------------------------ASVDLTIFSLHLAGVSSILG----AINFITTIINMKPPAMSQYQTPLFVWSMITAVLLLLSLPVLAAGITMLLTDRNLNTTF----FDPAGGGDPILYQHLFWFFGH------PEVYILILPGFGMISHIV----------TYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHH-------------MFTVG----------MDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSSDYPDAYTMWSMGSFISLTAVMLMVFIIWE 1vi0 A  0.323   12%        LRQKINEILKGYLNILDGILTEGIQSIKEGLDVRRQMIFGTIDETVTTWVMNDQKYDLVALSNSVLLLVSGIHNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------         TERTIARY STRUCTURE PREDICTION fugue       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   1pv6 A  3.34    7%   f.38.1.2     --------------------------------MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHIS---------------KSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALGASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFC---------------------------------------------------------------------------FFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLRRQVNEVA---------------------- 1q0v A  2.77   13%   j.105.1.1     ----------------------------------------------------------------------------------------------------------------------------------------MDRDYSTPEDEEELIRKAIELSLKESRNSASSEPIVPVVESKNEVKRQEIEEEEDPDLKAAIQESLREAEEAKLRSERQKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1sfc C  2.63    6%   h.1.15.1   59.2.1.1  -------------------------------------------------------------------------------------------------------------------------------------------MRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLDRVEEGMNHINQDMKEAEKNLKDLGK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2beq D  2.54   15%        --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1jth A  2.17   11%   h.1.15.1     -----------------------------------------------------------------------------------------------------------------------------------------------------------LEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1ya5 T  2.05   13%        -----------------------------------------------------------------------------------------------------------------------------------------------------------------------MATSELSSEVSEENSERREAFWAEWKDLTLSTRPEEGSSLHEEDTQRHETYHQQGQSQVLVQRSPWLMMRM-GILGRGLQEYQLPYQRVL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1n35 A  1.99   12%   e.8.1.4     LHAAASSSYSWFILKTKSIFPQNTLHSMYESLEGG----------------YCPNLEWLEPRSDYKFMYMGVMPLSAKYARSAPSN------DKKARELGEKYGL-SSVVGELRKRTKTYVKHDFASVRYIRDAMAC----TSGIFLVRTPTETVLQEYTQSP-----EIKVPIPQKDWTGPIGEIRILKDTTSSIARYLYRTWYLAAARMAAQP-RTWDPLFQAIMRSQYV--------TARGGSGAALRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPFSHTSVAILADTSMGLRNQ-------------VQRRPRSIMPLNVPQQQVSAPHTLTADYINYH------------------MNLSPTSGSAVIEKVIPLGVYASSPP------------NQSINIDISACDASITWDFFLSVIMAAIHEGVASSSIGKPFMGVPASIVNDESVVG------------VRAARPISGMQNMIQHLSKLYKR----GFSYRVNDSFSPGNDFTHMTTTFPSG----------STATSTEHTANNSTMMETFLTVWG 1zxa A  1.97   22%        ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2ba2 A  1.94    8%        -------------------------------------------------------------------------------------------------------------------------------------------GTRYVTHKQLDEKLKNFVTKTEFKEFQTVVMESFAVQNQNIDAQGEQIKELQVEQKAQGKTLQLILEALQGINKRLDNLES---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 1rya A  1.93    6%        -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMFLRQEDFATVVRSTPLVSLDFIVENSRGEFLLGKRVQKDETLEAAFERLTMAELGLRLPITQFYGVWQHFYDDNFSGTDFTTHYVVLGFRFRVSEEELLLPDEQHDDYRWLTSDALLASDNVHANSRAYFLAEKRTGVPGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------         TERTIARY STRUCTURE PREDICTION sp4       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   2bku B  6.02    8%        LVSIANAAAQLIAAIADIELMKIMVDNTGAEQPENVKRASLLALGYMCESADALVSSSNNILIAIVQGAQSRLAALNALADSLIGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSKYYTFMKPYMLYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSP------LQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGVMAFGSIMDGPDKVQRTYYVHQALPSILNLMND--------QSLQVKETTAWCIGRIA------------DSVAESIDPQQHLPGVVQACLIGL-QDHPKVATNCSWTIINLVEQLAEATPSPIYFYPALVDGLIANRIDNEFNARASAFSALTTMVEYAISTFVMDKLGQTMSVDENQLTLEDAQSL----QELQSNILTVLAAVIRKSPVADMLMGLFFRLKKDSAFIEDDVFYAISALAASLGKGFEYLETFSPYLLKALNQVDSP----VSITAVGFIADISNSLEYSDAMMMISNPNARRE--LKPAVLSVFGDIASNIGADFI 2a65 A  5.15    8%        ---------------------------REHWATRLGLILAMAGNAVGL---GNF------LRFPVQAAENGGGAFMIPYIIAFLVGIPLMWIEWAMGRYGGAQGHG--TTPAIFYLLWRNRFAKILFGLWIPLVVAIY------YVYIESWTLGFAIKFLVGL-------------VPEPPPTDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSIL--------------------------IRGISKGERFAKI----AMPTLFILAVFLVIRVFLL-----------ETPNGTAADGLNFLWT--PDFEKLKDPGVWIAAVGQIFFTL------SLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEV------ILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFI------------------TLPAIFSQTAGGTFLGFLWFFLLFFAGLTS------SIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLN---------KS-LDEMDFWAGTIGVVFFGLTELIIFF 1qgr A  5.09    7%   a.118.1.1   8.1.1.2  WPELIPQLVANVEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNS-----LEFTKANFDKESERHFIMQVVCEATQCTRVRVAALQNLVKIMSLYYQYMETYMALFAITIEAMWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYTLTKQDENDDDDDWNPCKACCEDDIVPHVLPFIKEHI-KNPDWRYRDAAVMAFGCILEGPEMPTLIELMKDPTAAWTVGRICELLPEAAINDVYIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVV------MASLLRMFSGGQEDALMAVSTLVEVLGGEFFKPFLGIGLKNYAE--YQVCLAAVGLVGDLCRALQSNIIPCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIYLEVVLNTLQ-QASQAQVYDMVDYLNELRESCLEAYTGIVQG 1kqf A  5.02    7%        RIS-WEEAFSRIAKLMKADRDANFIEKNECASGASNETGMLTQKFARSLGMLAVDNQARGPTVASLAPTFGRGAMTNHWVDIKNANVVMVMGGNAAEA-------HPVGFRWAMEAKNNNDATLIVVDPRFTRTAYAPIRSGTDITFLSGVLRYLIENNKINAETNASLLVRDDFAFEDGLFSGYDAEKRQYDKSSWNYQLDENGYAKRDETLTHPRCVWNLLKEHVSRYTPDVVENICGTPDFLKVCEVLASTSAPDRTTTFLWTQHTVGAQNIRTMAMIQLLIQGLTDLGL-LSTSLPGYLTLPSEKQVDLQSYLEANTPKATLADQVNYWSNYPKFFVSLMKSFYGDAQKENNWGYDWLPKWDQTYD---------VIKYFNMMDEGKVTG-YFCQGFNPVASFPDKNKVVSCLSKLKY--------MVVIDPLVTETSTFWQNHGESNDVDPASIQTEVFRLPSTCFAEEDGSNDGEILAGIYHHLRELYQSEGGKGVEPLMKMSW--------NYKQ--------PHEPQSDEVAKENN---------------G 1wa5 C  4.94    5%        EKASLNILFDVLLVLIKLYYDFNCQDIPEFFHASVLIKVKSSIQELVQLYTTRYEDVFGPMINEFIQITWNLISNQPKYDILVSKSLSFLTAVTRIPKYFEIESAMNNITEQIILPNVTEGTRRRACTDFLKELKEKN--EVLVTNIFLAHMKGFVDQYMSNWKFKDLYIYLFTALAINGNITNAGVSSTNNLLNVVDFFTKEIAPDLTSNNIPHIILRVDAIKYIYTFRNQ------LTKAQLIELMPILATFLQTD--------------EYVVYTYAAITIEKILTIR--ESNTSPAFIFHKEDISNS--TEILLKNLIALILKHGSSPEKLFLMRSIFRVLQTSEDSIQPLFQFIEIVTIMAKNPSNPRFTHYTFESIGAILNYTQEFIPYVFQIIAFVVEQSATIPEIKPLAQPLLAPNVWNIPAVTRLLKSFIKTDPVLGIFQRLIASKAYEVHGFDLLEHIMLLIDMNRLRPY-----IKQIAVLLLQRLQNSKTERYVKKLTVFFGLISNKLG--SDFLIHFIDEVQITTLPTIGNLLDRKIALIGVLNMVI 1jdh A  4.69    8%   a.118.1.1     MRSMVSAIVRTMQVETARCTAGTLHNL--SHHREGLLAIFGIPALVKM-LGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAG--------GLQKMVALLNKVKFLAITTDCLQILAYGNQESKLIILGGPQALVN--IMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWLSDAATKQEGMEGLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDR----------EDITEPAICALRHLT-----------------------SRHQEAEMAQNAVRLHLPVVVKLLHPPSHWPLIKATVGLIRNLAL-------CPANHAPLREQ-GAIPRLVQLLVRAHQDTQFVEGVRMEEIVEGCTGALHI--LARDVHNRIVIGLNTIPLFVQ-------LLYSPIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHS--RNEGVATYAAAVLFRMS-------------------------------------------------------------- 1u6g C  4.67    9%        VMSCFVDLIEHLLSELSYIQCIAAISIGEYLEKIIPLVVKFCLREYCIQAFESFPKEVYPHVSTIINICLKYLTYDMSW------------------------KVRRAAAKCLDAVVSTRHEMLPEFYVSPALISRFKEREENVKADVFHAYLSLLKQTRPVGETPLTMLQSQVPNIHKQMKEKSVLPGALTQH-IPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHVPPVVACVGDPITSEALLVTQQLVPSSFDATPYIKDLAADIDQEVKERAISCMGQIICNLGDNLGSDLPIAGSPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNY--SDSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYLQGGALSAMLDFFQALVVTLGYMDLLRMLTGPVQSYYSIAKCVAALTRACPEGPAVVGQFIQDVKSTDSIRLLALLSLGEVGHHILSGQL------ELKSVILEAFSSPSEEVKSAASYALGSIS---VGNLPEYLPF------VLQEITSQPKRQYLLLHSLKEIISS 1b3u A  4.58   10%   a.118.1.2   8.1.1.3  IKKLSTIALALGVERTRSELLPFLTDTIY-DEDEVLLALAEQL--GTFTTLVGGPEYVHCLLPPLESLAT--VEETVVRDKAVESLRAIS-------HEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVS-----SAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSE---------IIPMFSNLASDEQDSVRLLAVEACVNIAQLLPMPTLRQAAEDKRYMVAFTELQKAVGPEITDLAFQNLMKDCEAEVRAAASHK---VKEFCENL------------SADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFISNLDCVNEVIRQLSQSLLPAIVELAEDAKVRLAIIYMPLLAGQLGVEFFDEKLNSLCMAWVYAIREAATSNLKKLVEKFGAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPV-----ANVRFNVAKSLQKIGPI-------------LDNSTLQSE-------VKPILEKLTQD 1kqf A  4.44    8%        RIS-WEEAFSRIAKLMKADRDANFIEKNECASGASNETGMLTQKFARSLGMLAVDNQAHGPTVASLAPTFGRGAMTNHWVDIKNANVVMVMGG-------NAAEAHPVGFRWAMEAKNNNDATLI--------VVDPRFTRTADITFLSGVLRYLIENNKINAETNASLLVRDDFAFEDGLFSGYDAEKRQYDKSSWNYQLDENGYAKRDETLTHPRCVWNLLKEHVSRYTPDVVENICGTPDFLKVCEVLASTSAPDRTTT--FLYATVGAQNIRTMAMIQLLIQGLTDLGLLSTSLPGYLTLPSEKQVD--LQSYLEANTPKATDQVNYWSNYPKFFVSLMKSFYGDAAQKENNWGYDWLPKWDQTYD---------VIKYFNMMDEGKVTGYFCQGFNPVASFP----DKNKVVSCLSLKYMV------VIDPLVTETSTFWQNHGESNDVDPASIQTEVFRLPSTCFAEEDGSNDGEILAGIYHHLRELYQSEGGKGVEPLMKMSW--------NYKQ--------PHEPQSDEVAKENN---------------G 2is1 A  4.41   10%        MRHRIGQLMGMWVGTFHGLAHRLLRAHHMNLPQDFQILDSEDQLRLLKRLIDEKQWPPRQAMWYINSQKDEGLRPHHIQSYGNPVEQTWQKVYQAYQEACDRAGLFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTN------NIQYAWIRLLAGDTGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRST-----------------------------------SNILSAANALIENNNGRLGK---------------------------KLWTDGADGEPISLYCAFNELDEARFVVNRIKTWQDGALAECAIL-----------YRSNAQSRVLEEALLQRIYGGMRFFERQEIKDALSYLRLIVNRNDDAAFERVVVRQTSRDRQLTLWQACRELLQEKAL-----AGRAASALQR--FMELIDALAQETADMPLHVQTDRVIKDSGLRTMYGEKGQTRIENLEELVTATRQFSYDLMPLQAFLSHAALEAGEGQADTWQDAVQLMTKGLEFPQVFIVGMERLEEERRLAYVGVTR         TERTIARY STRUCTURE PREDICTION 3dpssm server not updated       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   1g3j A  0.13   11%   a.118.1.1   8.1.1.1  -------------HAVVNLINYQ--------DDAELATRAIPELTKLLNDEDVVNKAAVMVHQLSIMRSPQMVSAIVRTMQNTNDVETARCTGTLHNLSHHREGIFKSGGIPALVMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLA---ITTDCLQILAYGNQESKLIILASGGPQAL----VNIMRTYTYEKL-LWTTSRVLKVLSVCSSNKPAIV---EAGGMQALGLHLTDPSQRLVQNCLWTNLSDAAGLLGTLVQLLDINVVTCAAGILSNLTCNNYK--NKMMVCQVGGIEALVRTVDREDITEPAICALRHLTEAEMAQNAVRLHYGLPVVVLLHPPSHWPLIKATVGLIRNLAPLREQGAIPQLLVRAHQDTQRRFVEGVRMEEIVEG-CTG-ALHILARDVHNRIVIRGLNTIPLF----VQLLYSPIENIQRVAAGVLCELAQDKEAAIEAEGATAPLTELLH--SRNEGVATYAAAVLFRMSE-------------------------------------------- 1ee4 A  0.43   11%   a.118.1.1   8.1.1.1  --QELPQMTQQQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEEAAWALTNIAVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGYRDYVLQCNAMEPILLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTET----------------------------------------------------LVDACWAISYLSDGPQEAIQAVIDVRIP-KRLVELLSHESTLVQTPALR-----AVGNIVTGNDLQTQVVINAGV-LPALRLLLSSPKENIKKEACW----TISNITAGNTEQIQAVIDANLILVKLLEVAEDKTKKEACWAISNASSGGLQRPDIIRYLCIKPLCDLLEIADN-RIIEVTLDALENILKMGEA-DKEARGLNIN---------ENADFIEKAGGMEKI----FNCQQNENDKIYEKAYKIIETYF-------------------------------------------------------------------------------------- 1fft A  0.46   16%   f.24.1.1   1.5.14.1  ------------------------------------------------------------------------VDHKRLGIMYIIVAIVMLLRGFADAIMMHHY--DQIFAHGVIMIFVAMPFVIGLMNLVVPLQIGARVANNLS--FWFTVVGVILVNLGVGEFAQTGWLAYPPLSGIEYSPG----------------------------------VGVDYWIWSLQ---LSGIGT-TLTGIN-FFVTILKMRAPGMTMKMPVFTWASLC---ANVLIIASFPILTVTVALLTLDRYLGTHFFTNDM-----GGNMM--MYINLIAWGHPEILPVFGVFSEIAATFSRKRLFGLVWATVCITVLSFIVWLAGANVNAFFGITTMIIA---IPTGVKIFNWLFTMYQGRIV----FHSAMLWTIIVTFSVGGMTGVLLAVPGADFVLHNSLFLIAHFHNVIIGGVVFGCFAGMTGFKLNIGFFVAFMPLFMGMTRRLQIDPQFHTM-LMIAASGAIALPTSSPP-------PFYNF------------------------ 1b3u A  0.47   12%   a.118.1.2   8.1.1.3  ---------AAADYPIAVLI--DELR-----NEDVQLRLNSIKKLSTIALALGVERTRSELLP-FLTDTIYD------------EDEVLLALAEQLGTFTTLVGGPEYVLLPPLLATVEETVVRDKAVESLRAISH-EHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAEFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSLAVEACVNIAQLLPQLEALVMPTLRQAAEDKSWRVTELQKAVGPEITKTDLVAFQNLMKAEVRAAASHKVKEF-CENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVILLPAIVELAEDAKWRVRLAIIEYMPLLGQLGVEFFDEMAWLVDHVYNLKKLVEKFGAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAG--DPVANVRFNVAKSLQKIGPILDNSTLQSEVKPIL--EKLTQDQDVDVKYFAQEALTVLSLA-- 3bct  0.47   12%   a.118.1.1   8.1.1.1  -----------QVSAIVRTQTAGTLHNLSHHREGLLAIFKSGGIPALVKLGSPVDYAITTLHNLLAVRLAGGLQKV-ALLNKTNVKFLAITTDCLQILAYGNQESKLIIGPQALIRTYTYEKLLWTTSRVLK---VLSVCSSNKPAIVEAGGQALGLHL--------------------------------TDPSQRLVQNCLWTLRNLSDAATKQEGEGLLGTLVQL---------LGSDDINVVTCAAGILSNLTCNNYKNKVCQVG-GIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEAQNAVRLHYGLPVVVKLLHPPS--HWPLIKATVGLIRNLAL--------------------------CPANHAPLREQGAIPRLVQLLVRAH------QDTQRGVREEIVEGCTGALHILARDVHNRIVIRGLNTI-----PLFVQLLYSPIENIQRVAAGVLCELAQD-KEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFR---------------------------------------------- 1ial A  1.2   13%   a.118.1.1   8.1.1.1  -------------------------DEQMLKRRNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKT-------DCSPIQFESAWALTNIASGKAVVDGGAIPAFILLASPHAHISEQAVWALGNIAGDGSAFRD----LVIKHGAIDPL-------------------------------------------LALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPL-DAVEQILPTLVRLLHHNDPEVLADSCWAEMVVKKGVVPQLVKLLELPIVTPALRAIGN--IVTGTDEQTQKVIDAGALAVFPSLLTNPKIQKEATWTMSNITDQIQQVVNHG---LVPFLVGVLSKADFKTQKEAAWAI----TNYTSGGTVEQIVYLVHCGII---EPLM--NLLSAKDTKIIQVILDAISNIFQAAEKLGLSIMIEECIEALQRHENESVYKASLNLIEKYF-------------------------------------------------------------------------------------- 1ibr B  2.1   12%   a.118.1.1   8.1.1.2  --------------------------------------------------------ELITILEKTVSPDRLELEAAQKFLERAAVENLPFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDI--KAQYQQRWLAIDANA----RREVKNYVLQTLGTETYRP----------------------------------------------------SSASQCVAGIACAEIPVNQWPELIPQLV-----ANVTNPNST---EHMKESTLEAIGYICQDIPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN---SLEFTKANFDKESERHFIMQVVCEATQCPDALQNLVKIMMETYMGPALFDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHILTQTLTKQDENDDDDDWNPCKAAGVCLMEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEPEPSQLKPLVAMPTLIELMK--DPSVVVRDTAAWTVGRICELLP---------------------EAAINDVYLAPLLQCLIEG- 2occ A1  2.1   18%      1.5.14.1  -----------------------------------------------------------------MFIWLFSTNHKDIGTLY-----LLFGAAGMVGTAL---SLLIRAELGIYNVVVTAHAFVMIFFMVMIGGFGNWMANNMSFWLLPPSFLLLLASS-----------------------------MVEAGAGTGWTVYPPLAGNLAHAGASVD-LTIF-SLHLAGVSSILGAINFITTIINMKPPAMSQYQTP----------LFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDP-----AGGGDPI--LYQHL-----------FWFFGHPEVYILILPGF--GMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLG----FIVWAHH-----MFTVG-MDVDTRAYFTSATMI------IAIPTGVKV---FSWLA----TLHGGSPAMMLGFIFLFTVGLTGIVANSSLDIVLHDTYYVVA---HFH-YVLSMGAVFAIMGGFPLFSGYTLNAIMFMPRRYSYPDMWSMGLTAVMLMVFIIWLWLNT 1kpk A  3.9   15%   f.20.1.1     ----------------------------------------------------------------------------------------------------QAARLRRR--QLIRQLLRDKTPLAILFMAAVVGTL------VGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYVRKYAPEAGGSGIPEIEGALEDQRPVRWWR--VLPVKF---FGGLGTLGGGGPTVQIGGNIGRMVDIFRLKGDEARHTLLA----TGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFGVITIMYRIFGKLSDAPLNTLWLYLILGIIFIF--GPIFNKWVLGMQDLLHHGGNITKWVMGGAIGGLCGLLGFVAP---------ATSGGGFNLIPIATA-GNFSMGML----------VFIFV---ARVITTLLCFSSGAPGGIFAPMLALGTVLGT----------AFGMVAVELFPQYHLEAGTFAIAALLAASIGIIL--------VLEMTDNYQILPMIITGLGATLSAILARTLAL-- 1pw4 A  4.8   12%   f.38.1.1     ----------------------FKPAPHKARLPAAWQILGIFFGYAAYYL--------VRKNFALAMPYLGFSDLGFALSGI---SIAYGFSKFIMGSVSDRSN------PRVFLPAGLILAAAVMLFMGFVPWAT---SSIAV--MFVLLFLGWFQGMG------------------WPPCGRTMHWWSQKERGGIV-----------SVWNCAHNVGGGILLGMAWAAMPAFCAILV-----ALFAFAMMRDTPQSCGPIAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEY-------------AGIPGTLLCGWMFRGNVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIPVMLIGLHALELAPKKA--------AGTAAGFT------------GLFGYLGGSVAASAIVGYTVDFFGWGGFMVMIGGSILAVIL------------LIVVMIGLLQEL-VP------------------------------------------------------------         TERTIARY STRUCTURE PREDICTION inub       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   1b3u A  40.16    8%   a.118.1.2   8.1.1.3  KKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLAVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLANIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQLASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNS------------LCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGNVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALT--------------- 1g3j A  30.30    9%   a.118.1.1   8.1.1.1  HAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCT------AGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQ--ESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIGGMQALGLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQ----GAIPRLVQLLVRAHQDTQRRFVEGVRMEEIVEGCT---------GALHILARDVHNRIVIRGLNTIPLFVQLLYIENIQRVAAGVLCELA----QDKEAAEAIEAEGAT-APLTELLHSRN----------------------------------- 1w63 A  29.26    8%        ----RTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFV-QGLALCTLGCMGSSMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELL-------YFLDSCEPEFKADCASGIF-----LAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEETEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVN------------------------------------- 1pw4 A  24.25   12%   f.38.1.1     ------------------------KARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLFSRGDLGFALSGIS---IAYGFSKFIMGSVSDRSN-PRVFLPAGLILAAA--VMLFMGFVPWATMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKE-------------------------------------------------------RGGIVSVWNCA-----HNVGGGIPPLLFLLGMAWFND----------WLYMPAFCAILVALFAFAMMR---DTPQSCGLPPIEEYKNDTAKQIFMQYVLPN------------KLLWYIAIANVFVYLLR--YGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPG----------------------TLLCGWMSDKVFRGNRGATGVFFMTLVT---------IATIVYWMNPAGNPTVDMICMIVIGFLI--YGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAI-VG----YTVDFFGWDGGFMVMIGGSILAVILLIVVMIG--- 2bku B  23.14    8%        -QLIAAIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSKYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNIMAFGSIMDGPDKVQRTYYVHQALPSILNLMTTAWCIGRIADSVAESIDPQQHIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVPVSITAVGFIADISNSLEED-FRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALC---- 1pv6 A  20.15   11%   f.38.1.2     -------------------------------LKNTNFWMFGLFFFFYFF----IMGAYFPFFPIWLHDINHI-SKSDTGII----FAAISLFSLLFQPLFGL------LSDKL----GLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGI-----------------------------------YLGFCFNAGAPAVEAFIEKVSRRSNFEFGRA----RMFGCVGWALG----ASIVGIMFTI-----------NNQF-VFWLGSGCALILAVLL---FFAKTDAPSSATVANAVGANHSAFSLKLALEL--------FRQPKLWFLSLYVIGVSCTY--DVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLN---ASI---------------MFFAPLIINRIGGKNALLLAGTIMSVR---------------IIGSSFATSA-LEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSA-----TIYLVCFCFFKQLAMIF--MSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTL---- 1qbk B  20.07    8%   a.118.1.1   8.1.1.2  -------------ELLPHILPLLKELLFHHEWVVKESGILVLGAIA-----EGCMQGMIPYLPELIPHLIQCLSDKKALVRS---ITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACF----QHVKPCIADFMPILGTNLNPE-----------------FISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLE-----NTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMIS-VNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVG----------------------------------------- 1ehk A  18.47   13%   f.24.1.1   1.5.14.1  -------------------------------YPEKKATLYFLVLGFLALIVGSLFGPFQALYPLLKRLLPFVQSYGLTLHGVLNAIVFTQLFAQAIMVYLPARELNMRPNMGLMWL---SWWMAFIGLVVAALPL---LANEATVLTFYPPLKGWAFYLGASVFVLSTWVSIYIVLD----------LWRRWKAANPGKVTPLVTYMAVVFWLMWFLASLGLVLEAVLFLLPWSFG-LVEGVDPLVARTLFWWT----GHPIVYF-WLLPAYAIIYTILLVSDPMARLAFLLFLLLSTPVGFHHQFADPGIDPTWKMIHSVLT-LFVAVPSLMTAFTVAASLEFAGRLRGGRGLFGWIRALPWD-------NPAFVAPVLG-LLGFIPGGAGGIVNASF------------TLDYVVHNTAWVTLTAMGSLYWLLPNLTGKPISD--AQRRLGLAVVWLWFLGMMIMAVGLHWAGLLNPDAYPHAAVPMVFNVL--AGIVLLVALLLFIYGLFSVLLSRLAEAPLPFAEVISGPEVLAMDRIGFWFAVAAILVVLAYGPT 1ar1 A  16.73   11%   f.24.1.1   1.5.14.1  -------------------------------------ILYLFTAGIVGLISVCFTVYMRMELQMCLEGARLIADASATPNGHLWNVMITYHGVLMMFFVVIPA-LFGGFGNYFMPLHIGAPDMAFPRLNNLSYWMY-------VCGVALGVASLLADQMGSGVGWVLYPAIFAVHVSGASSILGAINIITTFLNMRAPGMTLFKVP----------LFAWSVFITAWL--ILLSLPVLAGAITMLLMDRNFGTQFFDPAGGGDPILWF-FGHPEVYIIILPGFGIISHVISTFAKKPIFGYLPMVLAMAAIGILGFVVWAHHMYTAGMSLTQQAYFMLATMTIAV--------PTGIKVFSWIATMWGGSIEFKTPMLWAFGFLFLFTVGG---------------VTGVVLSQAPLDRVYHDTYYVVAHFHYVMSLGAVFGIFAGVYYWIGKMSGYPEWAGQ---------LHFWMMFIGSNLIFFP--QHFLGRQGMPRRYIDYPVAYWNNISSI-------------GAYISFASF------LFFIGIVFYTLF--- 1fft A  15.24   14%   f.24.1.1   1.5.14.1  ------------------------------VDHKRLGIMYIIVAIVMLLRGFADAIMMRSQQALASAGEAGFLPPDQIFTA--HGVIMIFFVAMPFVIGL--------MNLVVPLQIGARDVAFPFLNNLSFWF-------TVVGVILVNVSLGVGEQTGWLAYPPLSGIEYSPGVGLQLSGIGTTLTGINFFVTILKMRAPGMTMFKMPVFTWASLCANVLIIA--------SFPILTVTVALLTLDRYLGTHFFTNDMGGNM---------MMYINLIWAWGHPEVY---ILILPVFGVF-----------SEIAATFSRKRLFGYTSLVWATVCITVLSFIVWLHHFFTMGAGANVNAFF------GITTMIIAIPTGVKIFNWLFTTIGFIVTFSVGGMTGVLLAVPGADFVLH----NSLFLIAHFHNVIIGGVVFGCFAGMTYWWPKAFGFKLNETWGKRAFWFWIIGFF---VAFMPLYALGFMGMTRRLQIDPQFHTM-LMIAASGAVLIALGILCLVIQM---YVSIRD----------------------         TERTIARY STRUCTURE PREDICTION pcons5       1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......     score identity scop fssp MATCWQGLWAYRMYLLVFLLPISLLPLPILVPRKEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGGLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAHAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRKNFGIREQEHEQQRKQAAYRVIQTQYRLLGPMSFAEKAVFILFVILVLLWFTREPGFFHGWGNLVFSDASGRVMVSDGSASILIGVFLFMVPSKIPGLTQDPDNPGRLKAPPALLNWKLVNKKMPWNIVLLLGGGYALAKGSEESGLSQWLGNKLMPLQHVPPPATVFIICLLVATFTECTSNAATTTLLLPILASMAQAICLHPLYVMLPCTLASSLAFMLPVATPPNAIVFSFGGLRVSDMARAGIMLNIIGVLVIMLAINS   2bku B  0.926    8%        -QLIAAIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSKYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNIMAFGSIMDGPDKVQRTYYVHQALPSILNLMTTAWCIGRIADSVAESIDPQQHIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANRIDAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVPVSITAVGFIADISNSLEED-FRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALC---- 1qgr A  0.9117    7%   a.118.1.1   8.1.1.2  WPELIPQLVANVEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNS-----LEFTKANFDKESERHFIMQVVCEATQCTRVRVAALQNLVKIMSLYYQYMETYMALFAITIEAMWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYTLTKQDENDDDDDWNPCKACCEDDIVPHVLPFIKEHI-KNPDWRYRDAAVMAFGCILEGPEMPTLIELMKDPTAAWTVGRICELLPEAAINDVYIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVV------MASLLRMFSGGQEDALMAVSTLVEVLGGEFFKPFLGIGLKNYAE--YQVCLAAVGLVGDLCRALQSNIIPCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIYLEVVLNTLQ-QASQAQVYDMVDYLNELRESCLEAYTGIVQG 2bku B  0.9116    8%        LVSIANAAAQLIAAIADIELMKIMVDNTGAEQPENVKRASLLALGYMCESADALVSSSNNILIAIVQGAQSRLAALNALADSLIGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSKYYTFMKPYMLYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSP------LQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGVMAFGSIMDGPDKVQRTYYVHQALPSILNLMND--------QSLQVKETTAWCIGRIA------------DSVAESIDPQQHLPGVVQACLIGL-QDHPKVATNCSWTIINLVEQLAEATPSPIYFYPALVDGLIANRIDNEFNARASAFSALTTMVEYAISTFVMDKLGQTMSVDENQLTLEDAQSL----QELQSNILTVLAAVIRKSPVADMLMGLFFRLKKDSAFIEDDVFYAISALAASLGKGFEYLETFSPYLLKALNQVDSP----VSITAVGFIADISNSLEYSDAMMMISNPNARRE--LKPAVLSVFGDIASNIGADFI 1ehk A  0.901   13%   f.24.1.1   1.5.14.1  -------------------------------YPEKKATLYFLVLGFLALIVGSLFGPFQALYPLLKRLLPFVQSYGLTLHGVLNAIVFTQLFAQAIMVYLPARELNMRPNMGLMWL---SWWMAFIGLVVAALPL---LANEATVLTFYPPLKGWAFYLGASVFVLSTWVSIYIVLD----------LWRRWKAANPGKVTPLVTYMAVVFWLMWFLASLGLVLEAVLFLLPWSFG-LVEGVDPLVARTLFWWT----GHPIVYF-WLLPAYAIIYTILLVSDPMARLAFLLFLLLSTPVGFHHQFADPGIDPTWKMIHSVLT-LFVAVPSLMTAFTVAASLEFAGRLRGGRGLFGWIRALPWD-------NPAFVAPVLG-LLGFIPGGAGGIVNASF------------TLDYVVHNTAWVTLTAMGSLYWLLPNLTGKPISD--AQRRLGLAVVWLWFLGMMIMAVGLHWAGLLNPDAYPHAAVPMVFNVL--AGIVLLVALLLFIYGLFSVLLSRLAEAPLPFAEVISGPEVLAMDRIGFWFAVAAILVVLAYGPT 1pv6 A  0.8725    7%   f.38.1.2     --------------------------------MYYLKNTNFWMFGLFFFFYFFIMGAYFPFFPIWLHDINHIS---------------KSDTGIIFAAISLFSLLFQPLFGLLSDKLGLRKYLLWIITGMLVMFAPFFIFIFGPLLQYNILVGSIVGGIYLGFFNAGAPAVEAFIEKVSRRSNFEFGRARMFGCVGWALGASIVGIMFTINNQFVFWLGSGCALILAVLLFFAKTDAPSSATVANAVGANHSAFSLKLALELFRQPKLWFLSLYVIGVSCTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIINRIGGKNALLLAGTIMSVRIIGSSFATSALEVVILKTLHMFEVPFLLVGCFKYITSQFEVRFSATIYLVCFC---------------------------------------------------------------------------FFKQLAMIFMSVLAGNMYESIGFQGAYLVLGLVALGFTLISVFTLSGPGPLSLLRRQVNEVA---------------------- 1b3u A  0.8492    8%   a.118.1.2   8.1.1.3  KKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLAVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLANIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQLASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNS------------LCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGNVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALT--------------- 1pw4 A  0.8259   10%   f.38.1.1     ----------------------------------------IFLGIFFGYAAYYLVRKNFALAMPYLVEQ-----------GFSRGDLGFALSGISIAYGFSKMGVSDRSNPRVFLPAG----LILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQK---------------------------------------------------GGIVSVWNCAHNVGGGIPPLLFLLGMA---------WFNDWHAALYMPAFCAILVALFAFAMM-------------RDTPQSCGLPPIEEYKNDYPDDYNEKAEQELTAKQIFMQYVL---------------------------------LLWYIAIANVFVYLLRYGILDWSPTYLKEVKH----------FALDKSSWAYFLYEYAGIPGTL-LCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYGAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVM-- 2occ A  0.8003   10%   f.24.1.1   1.5.14.1  ------------------------------------------------------------------------MFINRWL--FSTNTLYLLFGAW---AGMVGTALS-----LLIRAELGQPDQIYNVVVTAHAFVMIFFMVMPIVPLMIPRMNNMSFWL-LPPSFLLLLASSMVEAGGTGWTVYPPGNLAHAG------------------------ASVDLTIFSLHLAGVSSILG----AINFITTIINMKPPAMSQYQTPLFVWSMITAVLLLLSLPVLAAGITMLLTDRNLNTTF----FDPAGGGDPILYQHLFWFFGH------PEVYILILPGFGMISHIV----------TYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHH-------------MFTVG----------MDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSSDYPDAYTMWSMGSFISLTAVMLMVFIIWE 2a65 A  0.7835    8%        ---------------------------REHWATRLGLILAMAGNAVGL---GNF------LRFPVQAAENGGGAFMIPYIIAFLVGIPLMWIEWAMGRYGGAQGHG--TTPAIFYLLWRNRFAKILFGLWIPLVVAIY------YVYIESWTLGFAIKFLVGL-------------VPEPPPTDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSIL--------------------------IRGISKGERFAKI----AMPTLFILAVFLVIRVFLL-----------ETPNGTAADGLNFLWT--PDFEKLKDPGVWIAAVGQIFFTL------SLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEV------ILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFI------------------TLPAIFSQTAGGTFLGFLWFFLLFFAGLTS------SIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLN---------KS-LDEMDFWAGTIGVVFFGLTELIIFF 1u6g C  0.7788    8%        KEKSVKTRQCCFNMLTELVNV-----LPGAL--TQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNH--SPQVFHPHVQALVPPVVACVITSEAL-------LVTQQLVKVIRPLTPYIKDLFTCTIKRLKAADIDQEVKERAISCMGQIICNLGDNPNTLQIFLERLKNEITRLTTVKALTLIAG--SPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDIL-IKNYSDSLTAAMIDAVLDELPPLISESDMHVSQM----------------AISFLTTLAKVYPSSLSKISGSI----------LNELIGLVRSPLLQGGALSAMLDF--FQALVVTGTNNLGYMDLLRMLTGPVYSQTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSI--------RLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPE------YLPFVLQEIT--SQPKRQYLLLHSLKE--------------IISSASVVGLKPYVEN-----------IWALLLK