Calculation of Solvent Accessible Surface Areas, Atomic Solvation Energies and Their Gradients for Macromolecules

Robert Fraczkiewicz and Werner Braun

Sealy Center for Structural Biology
University of Texas Medical Branch
Galveston, TX 77555, USA

Quite often a biomolecular researcher wants to quickly calculate solvent accessible surface area or solvation energy of, for example, a protein molecule but does not have time/resources/skills/will to find and install an appropriate software. GETAREA, our efficient method of calculating the solvent accesible surface area [1,2] implemented in program FANTOM, can be directly accessed through this form. An on-line manual is available. Atomic coordinates should be supplied in PDB format. Please cite reference [1] in publications that use our service. Comments are welcome, please mail them to or

y or n, Default is n
For information purpose only

Please make sure that you are using standard amino acids and atoms name. A complete list is available here : HELP

Using multipe pdb files!

Users can use program to submit multiple PDB files to getarea server. Click this link to download program.


This service is provided freely to the scientific community for the purpose of scientific research. There is no warranty for the service, either expressed or implied. The entire risk as to the quality and performance of the service is with the user. In no event will Sealy Center for Structural Biology be liable for any damages, including any general, special or consequential damages arising out of the use, misuse, or inability to use of this service.


  1. Fraczkiewicz, R. and Braun, W. (1998) "Exact and Efficient Analytical Calculation of the Accessible Surface Areas and Their Gradients for Macromolecules" J. Comp. Chem., 19, 319-333.
  2. Fraczkiewicz, R. and Braun, W. "A New Efficient Algorithm for Calculating Solvent Accessible Surface Areas of Macromolecules" presented at the Third Electronic Computational Chemistry Conference; Northern Illinois University; November 1996; World Wide Web.

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